Kinevac Side Effects

Generic name: sincalide

Medically reviewed by Drugs.com. Last updated on Jul 11, 2023.

Note: This document contains side effect information about sincalide. Some dosage forms listed on this page may not apply to the brand name Kinevac.

Applies to sincalide: intravenous powder for solution.

Serious side effects of Kinevac

Along with its needed effects, sincalide (the active ingredient contained in Kinevac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sincalide:

Less common

Blurred vision
chest tightness
confusion
cough
difficulty swallowing
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
headache
hives, itching, skin rash
loss of consciousness
nervousness
numbness of the face, lips, and eyes
pounding in the ears
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
seizures
slow or fast heartbeat
stomach cramping
sweating
unusual tiredness or weakness

Other side effects of Kinevac

Some side effects of sincalide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Nausea
stomach discomfort or pain

Less common

Diarrhea
feeling of warmth
increased sweating
redness of the face, neck, arms, and occasionally, upper chest
sneezing
urge to defecate
vomiting

For Healthcare Professionals

Applies to sincalide: injectable powder for injection, intravenous powder for injection.

Gastrointestinal

Gastrointestinal side effects have included abdominal discomfort or pain and nausea. Rapid IV injection of 0.04 mcg sincalide (the active ingredient contained in Kinevac) per kg would be expected to cause transient abdominal cramping. These side effects are usually manifestations of the physiologic action of the drug, including delayed gastric emptying and increased intestinal motility. These side effects occurred in approximately 20% of patients but they are not to be construed as necessarily indicating an abnormality of the biliary tract unless there is other clinical or radiologic evidence of disease.^[Ref]

General

Reactions to sincalide (the active ingredient contained in Kinevac) are usually mild and of short duration. Adverse reactions including vomiting, flushing, sweating, rash, hypotension, hypertension, shortness of breath, urge to defecate, headache, diarrhea, sneezing, and numbness were less than 1%. Dizziness was reported in approximately 2% of patients. These manifestations are usually attenuated by a slower injection rate.^[Ref]